What or DLL error do you see on your screen? Are you trying to run a 32-bit or a 64-bit game? What model of controller are you attempting to configure?

Here is the definitive guide to resolving the Microsoft Visual C++ requirements for x360ce. 1. Why x360ce Requires Visual C++

Ensure x360ce isn't being blocked by Windows Defender, as it modifies DLL files in game folders, which can look suspicious to antivirus software.