Prevent future updates by navigating to SteamApps/common/Fallout 4 and setting your appmanifest_377160.acf file to "Read-Only". Method 2: The GOG DRM-Free Approach
The easiest way to get a "portable" version is to purchase the Game of the Year Edition on GOG. GOG allows you to: Download full, standalone offline installers. Disable automatic updates completely. fallout 4 patch 110163 portable
You can run multiple modded versions of Fallout 4 simultaneously (for instance, one vanilla and one heavily modded) by utilizing separate portable profiles. How to Achieve a Portable 1.10.163 Setup fallout 4 patch 110163 portable
A portable installation shifts the entire game environment away from system-locked directories. fallout 4 patch 110163 portable
Once you have the 1.10.163 files ready, do not place them in your default Program Files (x86)\Steam\steamapps\common\Fallout 4 folder if you want true portability.