One Piece Episode 722 -

The attack appears devastating, causing Doflamingo to cough up blood and struggle to remain standing, bringing an end to his temporary invincibility in the fight.

A celestial being who believes in absolute control, manipulation, and the subjugation of the weak. One Piece Episode 722

"Your loyalty is fierce," Fujitora said, walking past him. "But misplaced. Piracy is a poison. And your captain... he is the most infectious strain I have seen in decades." The attack appears devastating, causing Doflamingo to cough