If running for the first time, the first-time configuration wizard will appear. If not, navigate to (or Config > BIOS Selector on older versions).
Ensure you extract the files so that the .bin extension is directly visible. Double-check that your directory path in PCSX2 match exactly where the files are stored. 2. Game Fails to Load / Regional Mismatch
Using a USA v2.30 BIOS ensures maximum compatibility with North American NTSC game libraries, offering optimized timing, system fonts, and localized memory card configurations. The Legalities and Risks of Downloading BIOS Files
: While almost any BIOS (except the very first Japanese v1.00) works with PCSX2, the v2.30 is highly recommended for its stability with the North American library.
To use the PCSX2 Emulator legally, you must dump the BIOS directly from your own physical PlayStation 2 console. Why the BIOS is Required