What are you currently using (e.g., 2017.R3, 2021)? What color are the LEDs on your VCI unit? Are you getting a specific error code ?
Newer USB 3.0 (blue ports) or USB 3.1 ports can cause timing synchronization issues with older VCI architecture. Plug the device into an older USB 2.0 port, or use an unpowered USB 2.0 hub as an intermediary. delphi ds100e firmware update problem link
The Delphi DS100E (often referred to as part of the Delphi DS150E/DS100E diagnostic VCI family) is a robust tool, but users frequently encounter , particularly when upgrading software versions or using aftermarket/clone devices. A failed firmware update can leave your VCI (Vehicle Communication Interface) unresponsive, showing a "no VCI" error, or stuck in a flashing light loop. What are you currently using (e